| No | Size | Price | Availability | |
| MRM12370C-21S | 50ul | 1500.00 | In Stock |  |
| MRM12370C-21S | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 12370(Mouse) |
| Isotype: | IgG | Swiss Prot: | O89110 |
| purity: | Affinity purification |
| Background: |
| Apoptosis induced through the CD95 receptor (Fas/APO-1) and tumor necrosis factor receptor 1 (TNFR1) activates caspase-8 and leads to the release of the caspase-8 active fragments, p18 and p10 (1-3). Activated caspase-8 cleaves and activates downstream effector caspases such as caspase-1, -3, -6, and -7. Caspase-3 ultimately elicits the morphological hallmarks of apoptosis, including DNA fragmentation and cell shrinkage. |
| Reactivity | Mouse |
| Tested applications | WB IP IF FC |
| Clonality | Monoclonal Antibody |
| Calculated MW | 18, 43 kDa |
| Recommended Dilutions |
WB 1:1000
IF 1:800
FC 1:800
|
| Immunogen | A synthetic peptide corresponding to residues surrounding Asp387 of mouse caspase-8 protein |
| Storage | Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | MACH, Mch5, FLICE, CASP-8 |
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