| No | Size | Price | Availability | |
| ARMF028P-21 | 50ul | 1500.00 | In Stock |  |
| ARMF028P-21 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 2931/2932 |
| Isotype: | IgG | Swiss Prot: | P49840/P49841 |
| purity: | Affinity purification |
| Background: |
| Glycogen synthase kinase-3 (GSK-3) was initially identified as an enzyme that regulates glycogen synthesis in response to insulin (1). GSK-3 is a ubiquitously expressed serine/threonine protein kinase that phosphorylates and inactivates glycogen synthase. GSK-3 is a critical downstream element of the PI3K/Akt cell survival pathway whose activity can be inhibited by Akt-mediated phosphorylation at Ser21 of GSK-3α and Ser9 of GSK-3β (2,3). GSK-3 has been implicated in the regulation of cell fate in Dictyostelium and is a component of the Wnt signaling pathway required for Drosophila, Xenopus, and mammalian development (4). GSK-3 has been shown to regulate cyclin D1 proteolysis and subcellular localization (5). |
| Reactivity | Hamster, Human, Monkey, Mouse, Rat |
| Tested applications | WB IP |
| Clonality | Monoclonal Antibody |
| Calculated MW | 51, 46 kDa |
| Recommended Dilutions |
WB 1:1000
|
| Immunogen | A synthetic phosphopeptide corresponding to residues surrounding Ser21 of human GSK-3α protein |
| Storage | Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | / |
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