| No | Size | Price | Availability | |
| ARM51176P-21C | 50ul | 1500.00 | In Stock |  |
| ARM51176P-21C | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 51176 |
| Isotype: | IgG | Swiss Prot: | Q9UJU2 |
| purity: | Affinity purification |
| Background: |
| Lymphoid enhancer-binding factor 1(LEF1) belongs to a family of regulatory protein share homology with high mobility group protein-1, and it's a nuclear protein exprssed in pre-B and T cells. LEF1 has a role in the Wnt signaling pathway and hair cell differentiation and follicle morphogenesis. Together with CTNNB1 and EP300, LEF1 activates transcription of target genes. Isoform 5 transcriptionally activates the fibronectin promoter, binds to and represses transcription from the E-cadherin promoter in a CTNNB1-independent manner, and is involved in reducing cellular aggregation and increasing cell migration of pancreatic cancer cells. Isoform 1 transcriptionally activates MYC and CCND1 expression and enhances proliferation of pancreatic tumor cells |
| Reactivity | Human, Mouse, Rat |
| Tested applications | FC |
| Clonality | Monoclonal Antibody |
| Calculated MW | 37 kDa |
| Recommended Dilutions |
FC 1:50
|
| Immunogen | A synthetic peptide corresponding to residues surrounding Pro82 of human LEF1 protein |
| Storage | Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | KFZp586H0919, TCF1ALPHA |
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