Source: | Rabbit | Gene Id: | 23118 |
Isotype: | IgG | Swiss Prot: | Q9NYJ8 |
purity: | Affinity purification |
Background: |
The protein encoded by this gene is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, thus serves as an adaptor linking MAP3K7 and TRAF6. This protein, TAB1, and MAP3K7 also participate in the signal transduction induced by TNFSF11/RANKl through the activation of the receptor activator of NF-kappB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts. [provided by RefSeq |
Reactivity | Human, Monkey, Mouse, Rat |
Tested applications | WB IP |
Clonality | Monoclonal Antibody |
Calculated MW | 80-84 kDa |
Recommended Dilutions |
WB 1:1000
|
Immunogen | A synthetic peptide corresponding to residues surrounding Ser372 of human TAB2 protein |
Storage | Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles. |
Synonym | FLJ21885, KIAA0733, TAB2 |
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