| No | Size | Price | Availability | |
| ARM9019P-21 | 50ul | 1500.00 | In Stock |  |
| ARM9019P-21 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 9019 |
| Isotype: | IgG | Swiss Prot: | O95297 |
| purity: | Affinity purification |
| Background: |
| PZR (Protein zero related) is an immunoglobulin superfamily protein that specifically binds the tyrosine phosphatase SHP-2 through its intracellular immunoreceptor tyrosine-based inhibitory motifs (ITIMs) (1,2). PZR is phosphorylated by c-Src, c-Fyn, c-Lyn, Csk, and c-Abl (3). PP1, a Src family kinase inhibitor, inhibits PZR phosphorylation (4,5). There are three alternatively spliced isoforms, designated as PZR, PZRa, and PZRb; both PZRa and PZRb lack ITIMs (6,7). PZR is the main receptor of ConA and has an important role in cell signaling via c-Src (4). PZR is expressed in many cell types and is localized to cell contacts and intracellular granules in BAECs and mesothelioma (REN) cells. PZR has been implicated as a cell adhesion protein that may be involved in SHP-2-dependent signaling at interendothelial cell contacts (3). Hypertyrosine phosphorylation of PZR was observed during embryogenesis in a mouse model of Noonan syndrome (8).Upon Con A treatment or H2O2 treatment, two PZR intracellular ITIM tyrosine sites-Tyr241 and Tyr263 are phosphorylated (4,8). Phosphorylation of these two sites facilitates recruitment of SHP-2 to PZR which alters the phosphatase activity of SHP-2 and affects its downstream signaling (5,8,9). |
| Reactivity | Bovine, Human, Mouse, Rat |
| Tested applications | WB IP IF FC |
| Clonality | Monoclonal Antibody |
| Calculated MW | 30-50 kDa |
| Recommended Dilutions |
WB 1:1000
IF 1:800
FC 1:800
|
| Immunogen | A synthetic peptide corresponding to residues surrounding Tyr241 of human PZR protein |
| Storage | Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | FLJ21047, PZR, PZR1b, PZRa, PZRb |
沪ICP备15003525号 Copyright ©, 2013-2019, Yihyson All Rights Reserved. 
