Source: | Mouse | Gene Id: | 174 |
Isotype: | IgG2a | Swiss Prot: | P02771 |
purity: | Affinity purification |
Background: |
This gene encodes alpha-fetoprotein, a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with hepatoma or teratoma. However, hereditary persistance of alpha-fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and the alpha-fetoprotein and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. Alpha-fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of alpha-fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly. [provided by RefSeq |
Reactivity | Human, Mouse |
Tested applications | IF |
Clonality | Monoclonal Antibody |
Calculated MW | 70 kDa |
Recommended Dilutions |
IF 1:50
|
Immunogen | A recombinant fragment of human AFP |
Storage | Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles. |
Synonym | FETA, HPAFP |
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