Acetylated-Lysine Rabbit Monoclonal Antibody (HRP Conjugate)
No Size Price Availability  
AMMM001A-21C 50ul 1500.00 In Stock
AMMM001A-21C 100ul 2000.00 In Stock
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Source: Rabbit Gene Id: /
Isotype: IgG Swiss Prot: /
purity: Affinity purification
Background:
Acetylation of lysine, like phosphorylation of serine, threonine or tyrosine, is an important reversible modification controlling protein activity. The conserved amino-terminal domains of the four core histones (H2A, H2B, H3, and H4) contain lysines that are acetylated by histone acetyltransferases (HATs) and deacetylated by histone deacetylases (HDACs) (1). Signaling resulting in acetylation/deacetylation of histones, transcription factors, and other proteins affects a diverse array of cellular processes including chromatin structure and gene activity, cell growth, differentiation, and apoptosis (2-6). Recent proteomic surveys suggest that acetylation of lysine residues may be a widespread and important form of posttranslational protein modification that affects thousands of proteins involved in control of cell cycle and metabolism, longevity, actin polymerization, and nuclear transport (7,8). The regulation of protein acetylation status is impaired in cancer and polyglutamine diseases (9), and HDACs have become promising targets for anti-cancer drugs currently in development (10).
Reactivity All
Tested applications WB
Clonality Monoclonal Antibody
Calculated MW /
Recommended Dilutions
WB 1:1000
Immunogen A synthetic acetyl-lysine peptide library The antibody is formulated from two rabbit monoclones in order to cover broad range of reactivity
Storage Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles.
Synonym /
This product is for research use only, not for diagnostic or therapeutic use!

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