| No | Size | Price | Availability | |
| ARM64223-21C | 50ul | 1500.00 | In Stock |  |
| ARM64223-21C | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 64223 |
| Isotype: | IgG | Swiss Prot: | Q9BVC4 |
| purity: | Affinity purification |
| Background: |
| Cell growth is a fundamental biological process whereby cells accumulate mass and increase in size. The mammalian Target of Rapamycin (mTOR) pathway regulates growth by coordinating energy and nutrient signals with growth factor-derived signals (1). mTOR is a large protein kinase with two different complexes. One complex contains mTOR, GβL, and raptor, which is a target of rapamycin. The other complex, insensitive to rapamycin, includes mTOR, GβL, and rictor (1). GβL associates with the kinase domain of mTOR and stimulates mTOR kinase activity (2). A reduction in GβL expression has been shown to decrease in vivo phosphorylation of S6K1 (2). |
| Reactivity | Human, Monkey, Mouse, Rat |
| Tested applications | IP |
| Clonality | Monoclonal Antibody |
| Calculated MW | 37 kDa |
| Recommended Dilutions | |
| Immunogen | A synthetic peptide corresponding to residues surrounding Gln210 of human GβL |
| Storage | Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | GBL, LST8, MGC111011, POP3, WAT1 |
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