| No | Size | Price | Availability | |
| ARM558P-21 | 50ul | 1500.00 | In Stock |  |
| ARM558P-21 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 558 |
| Isotype: | IgG | Swiss Prot: | P30530 |
| purity: | Affinity purification |
| Background: |
| Axl, Sky, and Mer are three members of a receptor tyrosine kinase (RTK) family that share a conserved intracellular tyrosine kinase domain and an extracellular domain similar to those seen in cell adhesion molecules. These RTKs bind the vitamin K-dependent protein growth-arrest-specific 6 (Gas6), which is structurally related to the protein S anticoagulation factor (1). Upon binding to its receptor, Gas6 activates phosphatidylinositol 3-kinase (PI3K) and its downstream targets Akt and S6K, as well as NF-κB (2,3). A large body of evidence supports a role for Gas6/Axl signaling in cell growth and survival in normal and cancer cells (4). |
| Reactivity | Human |
| Tested applications | WB |
| Clonality | Monoclonal Antibody |
| Calculated MW | 138 kDa |
| Recommended Dilutions |
WB 1:1000
|
| Immunogen | A synthetic phosphopeptide corresponding to residues surrounding Tyr702 of human Axl protein |
| Storage | Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | AXL, JTK11, UFO |
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