| No | Size | Price | Availability | |
| ARM1267-21C | 50ul | 1500.00 | In Stock |  |
| ARM1267-21C | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 1267 |
| Isotype: | IgG | Swiss Prot: | P09543 |
| purity: | Affinity purification |
| Background: |
| CNPase (2', 3’-cyclic nucleotide 3'-phosphodiesterase) catalyzes the in vitro hydrolysis of 2’, 3’-cyclic nucleotides to produce 2’-nucleotides. The in vivo molecular function and native substrate of this nucleotide phosphodiesterase remains under investigation (1). High CNPase expression is seen in oligodendrocytes and Schwann cells as CNPase accounts for roughly 4% of the total myelin protein in the central nervous system (2). CNPase binds to tubulin heterodimers and plays a role in tubulin polymerization, and oligodendrocyte process outgrowth (3). Typical myelination is seen in CNPase knock-out mice, but they suffer severe neurodegeneration from axonal loss and oligodendrocytes display abnormal paranodal loop structure prior to axonal degeneration. Paranodal loops typically contact the axolemma in axon-glial signaling; neurodegeneration in CNPase knock-out mice is a secondary consequence of impaired cell-cell communication (4). |
| Reactivity | Human, Mouse, Rat |
| Tested applications | IF |
| Clonality | Monoclonal Antibody |
| Calculated MW | 48 kDa |
| Recommended Dilutions |
IF 1:50
|
| Immunogen | A synthetic peptide corresponding to residues surrounding Val81 of human CNPase protein |
| Storage | Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | CNP, CNPase |
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