Phospho-SGK1-Ser78 Rabbit Monoclonal Antibody
No Size Price Availability  
ARM6446P-21 50ul 1500.00 In Stock
ARM6446P-21 100ul 2000.00 In Stock
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Source: Rabbit Gene Id: 6446
Isotype: IgG Swiss Prot: O00141
purity: Affinity purification
Background:
Serum and glucocorticoid-inducible kinase (SGK) is a serine/threonine kinase closely related to Akt (1). SGK is rapidly induced in response to a variety of stimuli, including serum, glucocorticoid, follicle stimulating hormone, osmotic shock, and mineralocorticoids. SGK activation can be accomplished via HGF PI3K-dependent pathways and by integrin-mediated PI3K-independent pathways (2,3). Induction and activation of SGK has been implicated in activating the modulation of anti-apoptotic and cell cycle regulation (4-6). SGK also plays an important role in activating certain potassium, sodium, and chloride channels, suggesting its involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion (2). SGK is negatively regulated by ubiquitination and proteasome degradation (7).The MAP kinase family member BMK1 interacts with and activates SGK by phosphorylation at serine 78 (6).
Reactivity Human
Tested applications WB IP
Clonality Monoclonal Antibody
Calculated MW 54 kDa
Recommended Dilutions
WB 1:1000
Immunogen A synthetic phosphopeptide corresponding to residues surrounding Ser78 of human SGK1 protein
Storage Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles.
Synonym SGK, SGK1
This product is for research use only, not for diagnostic or therapeutic use!

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