| No | Size | Price | Availability | |
| ARM10376A-21 | 50ul | 1500.00 | In Stock |  |
| ARM10376A-21 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 10376 |
| Isotype: | IgG | Swiss Prot: | P68363 |
| purity: | Affinity purification |
| Background: |
| The cytoskeleton consists of three types of cytosolic fibers: microtubules, microfilaments (actin filaments), and intermediate filaments. Globular tubulin subunits comprise the microtubule building block, with α/β-tubulin heterodimers forming the tubulin subunit common to all eukaryotic cells. γ-tubulin is required to nucleate polymerization of tubulin subunits to form microtubule polymers. Many cell movements are mediated by microtubule action, including the beating of cilia and flagella, cytoplasmic transport of membrane vesicles, chromosome alignment during meiosis/mitosis, and nerve-cell axon migration. These movements result from competitive microtubule polymerization and depolymerization or through the actions of microtubule motor proteins (1).The Elongator complex catalytic subunit (Elp3) acetylates α-tubulin at Lys40 while the histone deacetylase HDAC6 functions as a tubulin deacetylase. This post-transcriptional modification may be required for dynamic cell shape remodeling, cell motility, tubulin stability and terminal branching of cortical neurons (2,3). |
| Reactivity | Human, Monkey, Mouse, Rat, Zebrafish |
| Tested applications | WB IP IF |
| Clonality | Monoclonal Antibody |
| Calculated MW | 52 kDa |
| Recommended Dilutions |
WB 1:1000
IF 1:800
|
| Immunogen | A synthetic acetylpeptide corresponding to residues surrounding Lys40 of human α-tubulin |
| Storage | Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | K-ALPHA-1 |
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