KDR Rabbit Monoclonal Antibody (Sepharose Bead Conjugate)
No Size Price Availability  
ARM3791-21C 50ul 1500.00 In Stock
ARM3791-21C 100ul 2000.00 In Stock
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Source: Rabbit Gene Id: 3791
Isotype: IgG Swiss Prot: P35968
purity: Affinity purification
Background:
Vascular endothelial growth factor receptor 2 (VEGFR2, KDR, Flk-1) is a major receptor for VEGF-induced signaling in endothelial cells. Upon ligand binding, VEGFR2 undergoes autophosphorylation and becomes activated (1). Major autophosphorylation sites of VEGFR2 are located in the kinase insert domain (Tyr951/996) and in the tyrosine kinase catalytic domain (Tyr1054/1059) (2). Activation of the receptor leads to rapid recruitment of adaptor proteins, including Shc, GRB2, PI3 kinase, NCK, and the protein tyrosine phosphatases SHP-1 and SHP-2 (3). Phosphorylation at Tyr1212 provides a docking site for GRB2 binding and phospho-Tyr1175 binds the p85 subunit of PI3 kinase and PLCγ, as well as Shb (1,4,5). Signaling from VEGFR2 is necessary for the execution of VEGF-stimulated proliferation, chemotaxis and sprouting, as well as survival of cultured endothelial cells in vitro and angiogenesis in vivo (6-8).
Reactivity Human, Mouse
Tested applications IP
Clonality Monoclonal Antibody
Calculated MW 210, 230 kDa
Recommended Dilutions
Immunogen A recombinant protein containing the carboxy-terminal 150 amino acid residues of human VEGF receptor 2 protein
Storage Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles.
Synonym FLK1, CD309, VEGFR, VEGFR2
This product is for research use only, not for diagnostic or therapeutic use!

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