| No | Size | Price | Availability | |
| ARM55920-21 | 50ul | 1500.00 | In Stock |  |
| ARM55920-21 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 55920 |
| Isotype: | IgG | Swiss Prot: | Q9P258 |
| purity: | Affinity purification |
| Background: |
| RCC2/TD-60 is a member of the RCC1 (regulator of chromosome condensation 1) family of guanine nucleotide exchange factors. RCC2/TD-60 is associated with the chromosome passenger complex (CPC), which also consists of aurora B kinase, borealin, INCENP (inner centromere protein) and survivin. The CPC acts at various stages of mitosis, interacts with microtubules and is required for proper chromosome segregation and cytokinesis. Regulation of aurora B kinase is key in the regulation of the CPC (reviewed in 1,2). In late mitosis, RCC2/TD-60 is required for spindle assembly and recruitment of survivin and aurora B (3). RCC2/TD-60 is also required for aurora B activation in vitro and localization of the CPC to centromeres (4). |
| Reactivity | Human, Monkey, Mouse, Rat |
| Tested applications | WB IF |
| Clonality | Monoclonal Antibody |
| Calculated MW | 60 kDa |
| Recommended Dilutions |
WB 1:1000
IF 1:100
|
| Immunogen | A synthetic peptide corresponding to residues near the carboxy terminus of human RCC2 protein |
| Storage | Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | TD-60 |
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