Source: | Rabbit | Gene Id: | 10376 |
Isotype: | IgG | Swiss Prot: | P68363 |
purity: | Affinity purification |
Background: |
The cytoskeleton consists of three types of cytosolic fibers: microtubules, microfilaments (actin filaments), and intermediate filaments. Globular tubulin subunits comprise the microtubule building block, with α/β-tubulin heterodimers forming the tubulin subunit common to all eukaryotic cells. γ-tubulin is required to nucleate polymerization of tubulin subunits to form microtubule polymers. Many cell movements are mediated by microtubule action, including the beating of cilia and flagella, cytoplasmic transport of membrane vesicles, chromosome alignment during meiosis/mitosis, and nerve-cell axon migration. These movements result from competitive microtubule polymerization and depolymerization or through the actions of microtubule motor proteins (1). |
Reactivity | Bovine, D. melanogaster, Human, Monkey, Mouse, Rat |
Tested applications | IF FC |
Clonality | Monoclonal Antibody |
Calculated MW | 52 kDa |
Recommended Dilutions |
IF 1:100
FC 1:50
|
Immunogen | A synthetic phosphopeptide corresponding to the amino terminus of human α-tubulin protein |
Storage | Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles. |
Synonym | K-ALPHA-1 |
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