ARRB1/2 Rabbit Monoclonal Antibody
No Size Price Availability  
ARMF032-21 50ul 1500.00 In Stock
ARMF032-21 100ul 2000.00 In Stock
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Source: Rabbit Gene Id: 408/409
Isotype: IgG Swiss Prot: P49407/P32121
purity: Affinity purification
Background:
Arrestin proteins function as negative regulators of G protein-coupled receptor (GPCR) signaling. Cognate ligand binding stimulates GPCR phosphorylation, which is followed by binding of arrestin to the phosphorylated GPCR and the eventual internalization of the receptor and desensitization of GPCR signaling (1). Four distinct mammalian arrestin proteins are known. Arrestin 1 (also known as S-arrestin) and arrestin 4 (X-arrestin) are localized to retinal rods and cones, respectively. Arrestin 2 (also known as β-arrestin 1) and arrestin 3 (β-arrestin 2) are ubiquitously expressed and bind to most GPCRs (2). β-arrestins function as adaptor and scaffold proteins and play important roles in other processes, such as recruiting c-Src family proteins to GPCRs in Erk activation pathways (3,4). β-arrestins are also involved in some receptor tyrosine kinase signaling pathways (5-8). Additional evidence suggests that β-arrestins translocate to the nucleus and help regulate transcription by binding transcriptional cofactors (9,10).
Reactivity Human, Monkey, Mouse, Rat
Tested applications WB IP
Clonality Monoclonal Antibody
Calculated MW 50 kDa
Recommended Dilutions
WB 1:1000
Immunogen A recombinant protein containing the carboxy-terminal region of human β-arrestin 1
Storage Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles.
Synonym /
This product is for research use only, not for diagnostic or therapeutic use!

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