Phospho-FLT3-Tyr842 Rabbit Monoclonal Antibody
No Size Price Availability  
ARM2322P-22 50ul 1500.00 In Stock
ARM2322P-22 100ul 2000.00 In Stock
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Source: Rabbit Gene Id: 2322
Isotype: IgG Swiss Prot: P36888
purity: Affinity purification
Background:
This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. The receptor consists of an extracellular domain composed of five immunoglobulin-like domains, one transmembrane region, and a cytoplasmic kinase domain split into two parts by a kinase-insert domain. The receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. [provided by RefSeq
Reactivity Human, Mouse
Tested applications WB IP
Clonality Monoclonal Antibody
Calculated MW 160 kDa
Recommended Dilutions
WB 1:1000
Immunogen A synthetic phosphopeptide corresponding to the sequence surrounding Tyr842 of human FLT3
Storage Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles.
Synonym CD135, FLK2, STK1
This product is for research use only, not for diagnostic or therapeutic use!

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