| No | Size | Price | Availability | |
| ARM5728-23C | 50ul | 1500.00 | In Stock |  |
| ARM5728-23C | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 5728 |
| Isotype: | IgG | Swiss Prot: | P60484 |
| purity: | Affinity purification |
| Background: |
| This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. |
| Reactivity | Dog, Human, Monkey, Mouse, Rat |
| Tested applications | IP |
| Clonality | Monoclonal Antibody |
| Calculated MW | 54 kDa |
| Recommended Dilutions | |
| Immunogen | A synthetic peptide corresponding to residues in the carboxy-terminal sequence of human PTEN |
| Storage | Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | BZS, DEC, GLM2, MHAM, TEP1, MMAC1, PTEN1, 10q23del |
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