| No | Size | Price | Availability | |
| AMM17760-21 | 50ul | 1500.00 | In Stock |  |
| AMM17760-21 | 100ul | 2000.00 | In Stock | |
| Source: | Mouse | Gene Id: | 17760(Mouse) |
| Isotype: | IgG1 | Swiss Prot: | Q7TSJ2 |
| purity: | Affinity purification |
| Background: |
| Stable Tubule Only Polypeptide (STOP) is a microtubule-associated protein, and its microtubule-stabilizing activity is regulated by calmodulin (1-2). STOPs have several tissue- and developmental-specific isoforms that are encoded by a single gene. Neurons express N-STOP (exons 1-4) and E-STOP (exons 1-3), fibroblasts express F-STOP (exons 1-2), oligodendrocytes express O-STOP, and astrocytes A-STOP (3). STOPs are the major contributors stabilizing microtubules that resist depolymerization due to cold or depolymerizing drugs. STOP knock-out mice display impaired synaptic plasticity associated with severe behavioral disorders in contrast to the anticipated neuronal development and brain anatomy defects (4). |
| Reactivity | Human, Mouse, Rat |
| Tested applications | WB IF |
| Clonality | Monoclonal Antibody |
| Calculated MW | 120 kDa |
| Recommended Dilutions |
WB 1:1000
IF 1:200
|
| Immunogen | purified N-STOP from rat brain The antigen is encoded by exon 4 (Galiano et al, 2004) |
| Storage | Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | / |
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