| No | Size | Price | Availability | |
| ARM1499P-22 | 50ul | 1500.00 | In Stock |  |
| ARM1499P-22 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 1499 |
| Isotype: | IgG | Swiss Prot: | P35222 |
| purity: | Affinity purification |
| Background: |
| β-catenin is an adherens junction protein. Adherens junctions (AJs; also called the zonula adherens) are critical for the establishment and maintenance of epithelial layers, such as those lining organ surfaces. AJs mediate adhesion between cells, communicate a signal that neighboring cells are present, and anchor the actin cytoskeleton. In serving these roles, AJs regulate normal cell growth and behavior. At several stages of embryogenesis, wound healing, and tumor cell metastasis, cells form and leave epithelia. This process, which involves the disruption and reestablishment of epithelial cell-cell contacts, may be regulated by the disassembly and assembly of AJs. AJs may also function in the transmission of the 'contact inhibition' signal, which instructs cells to stop dividing once an epithelial sheet is complete.[supplied by OMIM |
| Reactivity | Human |
| Tested applications | WB IP IF |
| Clonality | Monoclonal Antibody |
| Calculated MW | 92 kDa |
| Recommended Dilutions |
WB 1:1000
IF 1:100
|
| Immunogen | A synthetic phosphopeptide corresponding to residues surrounding Ser675 of human β-catenin |
| Storage | Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | CTNNB, DKFZp686D02253, FLJ25606, FLJ37923, β-catenin |
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