| No | Size | Price | Availability | |
| ARMF013P-21C | 50ul | 1500.00 | In Stock |  |
| ARMF013P-21C | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 1432/5600/5603/6300 |
| Isotype: | IgG | Swiss Prot: | Q16539/Q15759/O15264/P53778 |
| purity: | Affinity purification |
| Background: |
| p38 MAP kinase (MAPK), also called RK (1) or CSBP (2), is the mammalian orthologue of the yeast HOG kinase that participates in a signaling cascade controlling cellular responses to cytokines and stress (1-4). Four isoforms of p38 MAPK, p38α, β, γ (also known as Erk6 or SAPK3), and δ (also known as SAPK4) have been identified. Similar to the SAPK/JNK pathway, p38 MAPK is activated by a variety of cellular stresses including osmotic shock, inflammatory cytokines, lipopolysaccharide (LPS), UV light, and growth factors (1-5). MKK3, MKK6, and SEK activate p38 MAPK by phosphorylation at Thr180 and Tyr182. Activated p38 MAPK has been shown to phosphorylate and activate MAPKAP kinase 2 (3) and to phosphorylate the transcription factors ATF-2 (5), Max (6), and MEF2 (5-8).SB203580 (4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)-imidazole) is a selective inhibitor of p38 MAPK. This compound inhibits the activation of MAPKAPK-2 by p38 MAPK and subsequent phosphorylation of HSP27 (9). SB203580 inhibits p38 MAPK catalytic activity by binding to the ATP-binding pocket, but does not inhibit phosphorylation of p38 MAPK by upstream kinases (10). |
| Reactivity | D. melanogaster, Human, Monkey, Mouse, Pig, Rat, S. cerevisiae |
| Tested applications | WB FC |
| Clonality | Monoclonal Antibody |
| Calculated MW | 43 kDa |
| Recommended Dilutions |
WB 1:1000
FC 1:200
|
| Immunogen | A synthetic phosphopeptide corresponding to residues surrounding Thr180/Tyr182 of human p38 MAPK |
| Storage | Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | / |
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