| No | Size | Price | Availability | |
| ARMF012P-21C | 50ul | 1500.00 | In Stock |  |
| ARMF012P-21C | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 5604/5605 |
| Isotype: | IgG | Swiss Prot: | Q02750/P36507 |
| purity: | Affinity purification |
| Background: |
| MEK1 and MEK2, also called MAPK or Erk kinases, are dual-specificity protein kinases that function in a mitogen activated protein kinase cascade controlling cell growth and differentiation (1-3). Activation of MEK1 and MEK2 occurs through phosphorylation of two serine residues at positions 217 and 221, located in the activation loop of subdomain VIII, by Raf-like molecules. MEK1/2 is activated by a wide variety of growth factors and cytokines and also by membrane depolarization and calcium influx (1-4). Constitutively active forms of MEK1/2 are sufficient for the transformation of NIH/3T3 cells or the differentiation of PC-12 cells (4). MEK activates p44 and p42 MAP kinase by phosphorylating both threonine and tyrosine residues at sites located within the activation loop of kinase subdomain VIII. |
| Reactivity | D. melanogaster, Human, Monkey, Mouse, Rat |
| Tested applications | WB IP |
| Clonality | Monoclonal Antibody |
| Calculated MW | 45 kDa |
| Recommended Dilutions |
WB 1:1000
|
| Immunogen | A synthetic phosphopeptide corresponding to residues around Ser217/221 of human MEK1/2 |
| Storage | Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | CFC3/CFC4, MEK1/MEK2, MKK1/MKK2, MAPKK1/MAPKK2, PRKMK1/PRKMK2 |
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