| No | Size | Price | Availability | |
| ARM253260P-21 | 50ul | 1500.00 | In Stock |  |
| ARM253260P-21 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 253260 |
| Isotype: | / | Swiss Prot: | Q6R327 |
| purity: | Affinity purification |
| Background: |
| Cell growth is a fundamental biological process whereby cells accumulate mass and increase in size. The mammalian TOR (mTOR) pathway regulates growth by coordinating energy and nutrient signals with growth factor-derived signals (1). mTOR is a large protein kinase with two different complexes. One complex contains mTOR, GβL and raptor, which is a target of rapamycin. The other complex, insensitive to rapamycin, includes mTOR, GβL, Sin1, and rictor (1). The mTOR-rictor complex phosphorylates Ser473 of Akt/PKB in vitro (2). This phosphorylation is essential for full Akt/PKB activation. Furthermore, an siRNA knockdown of rictor inhibits Ser473 phosphorylation in 3T3-L1 adipocytes (3). This complex has also been shown to phosphorylate the rapamycin-resistant mutants of S6K1, another effector of mTOR (4). |
| Reactivity | Human, Monkey, Mouse |
| Tested applications | WB |
| Clonality | Monoclonal Antibody |
| Calculated MW | 200 kDa |
| Recommended Dilutions |
WB 1:1000
|
| Immunogen | A synthetic peptide corresponding to residues surrounding Thr1135 of human rictor protein |
| Storage | Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | DKFZp686B11164, KIAA1999, MGC39830, mAVO3 |
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