| No | Size | Price | Availability | |
| ARM26986AM-21 | 50ul | 1500.00 | In Stock |  |
| ARM26986AM-21 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 26986 |
| Isotype: | IgG | Swiss Prot: | P11940 |
| purity: | Affinity purification |
| Background: |
| The poly(A)-binding protein (PABP), which is found complexed to the 3-prime poly(A) tail of eukaryotic mRNA, is required for poly(A) shortening and translation initiation [PMID: 21989405]. Polyadenylate-binding protein 1 (PABPC1) is a cytoplasmic-nuclear shuttling protein important for protein translation initiation, and both RNA processing and stability. In the cytoplasm, PABPC1 binds to the 3' poly(A) tail of eukaryotic mRNAs through its RNA-recognition motifs (RRM) and interacts with the N-terminus of eIF4G, part of the eIF4F complex associated with the 5' cap structure [PMID:20009508, 17381337]. |
| Reactivity | Human, Monkey, Mouse, Rat |
| Tested applications | WB IHC IP IF |
| Clonality | Monoclonal Antibody |
| Calculated MW | 71 kDa |
| Recommended Dilutions |
WB 1:1000
IHC 1:1000
IF 1:400
|
| Immunogen | A synthetic peptide corresponding to the sequence of human PABP1 in which Arg455 and Arg460 are methylated |
| Storage | Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | PAB1, PABP, PABP1, PABPC2, PABPL1 |
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