| No | Size | Price | Availability | |
| ARM9451P-21 | 50ul | 1500.00 | In Stock |  |
| ARM9451P-21 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 9451 |
| Isotype: | IgG | Swiss Prot: | Q9NZJ5 |
| purity: | Affinity purification |
| Background: |
| PERK (protein kinase-like endoplasmic reticulum kinase) is an eIF2α kinase and transmembrane protein resident in the endoplasmic reticulum (ER) membrane that couples ER stress signals to translation inhibition (1-3). ER stress increases the activity of PERK, which then phosphorylates eIF2α to promote reduced translation. PERK-deficient mice have defects in pancreatic β cells several weeks after birth, suggesting a role for PERK-mediated translational control in protecting secretory cells from ER stress (4). PERK activation during ER stress correlates with autophosphorylation of its cytoplasmic kinase domain (1-3). Phosphorylation of PERK at Thr980 serves as a marker for its activation status. |
| Reactivity | Rat |
| Tested applications | WB |
| Clonality | Monoclonal Antibody |
| Calculated MW | 170 kDa |
| Recommended Dilutions |
WB 1:1000
|
| Immunogen | A synthetic phosphopeptide corresponding to residues surrounding Thr980 of mouse PERK |
| Storage | Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | EIF2AK3, DKFZp781H1925, HRI, PEK, PERK, WRS |
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