| No | Size | Price | Availability | |
| ARM1436P-21 | 50ul | 1500.00 | In Stock |  |
| ARM1436P-21 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 1436 |
| Isotype: | IgG | Swiss Prot: | P07333 |
| purity: | Affinity purification |
| Background: |
| Macrophage-colony stimulating factor (M-CSF, CSF-1) receptor is an integral membrane tyrosine kinase encoded by the c-fms proto-oncogene. M-CSF receptor is expressed in monocytes (macrophages and their progenitors) and drives growth and development of this blood cell lineage. (1-3). Binding of M-CSF to its receptor induces receptor dimerization, activation, and autophosphorylation of cytoplasmic tyrosine residues used as docking sites for SH2-containing signaling proteins (4). There are at least five major tyrosine autophosphorylation sites. Tyr723 (Tyr721 in mouse) is located in the kinase insert (KI) region. Phosphorylated Tyr723 binds the p85 subunit of PI3 kinase as well as PLCγ2 (5). Phosphorylation of Tyr809 provides a docking site for Shc (5). Overactivation of this receptor can lead to a malignant phenotype in various cell systems (6). The activated M-CSF receptor has been shown to be a predictor of poor outcome in advanced epithelial ovarian carcinoma (7) and breast cancer (8). |
| Reactivity | Human, Mouse |
| Tested applications | WB IHC IP FC |
| Clonality | Monoclonal Antibody |
| Calculated MW | 175 kDa |
| Recommended Dilutions |
WB 1:1000
IHC 1:75
FC 1:800
|
| Immunogen | A synthetic phosphopeptide corresponding to residues surrounding Tyr723 of human M-CSF receptor |
| Storage | Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | FMS, CSFR, FIM2, HDLS, C-FMS, CD115, CSF-1R, M-CSF-R |
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