| No | Size | Price | Availability | |
| ARMM012P-23 | 50ul | 1500.00 | In Stock |  |
| ARMM012P-23 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | / |
| Isotype: | IgG | Swiss Prot: | / |
| purity: | Affinity purification |
| Background: |
| Ataxia telangiectasia mutated kinase (ATM) and ataxia telangiectasia and Rad3-related kinase (ATR) are related kinases that regulate cell cycle checkpoints and DNA repair (1). The identified substrates for ATM are p53, p95/NBS1, MDM2, Chk2, BRCA1, CtIP, 4E-BP1, and Chk1 (1,2) The essential requirement for the substrates of ATM/ATR is S*/T*Q. Hydrophobic amino acids at positions -3 and -1, and negatively charged amino acids at position +1 are positive determinants for substrate recognition by these kinases. Positively charged residues surrounding the S*/T*Q are negative determinants for substrate phosphorylation (3). The complex phenotype of AT cells suggests that it likely has additional substrates (3). |
| Reactivity | All |
| Tested applications | WB |
| Clonality | Monoclonal Antibody |
| Calculated MW | / |
| Recommended Dilutions |
WB 1:1000
|
| Immunogen | A synthetic phospho-ATM/ATR substrate peptides |
| Storage | Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | / |
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