| No | Size | Price | Availability | |
| ARM596P-21C | 50ul | 1500.00 | In Stock |  |
| ARM596P-21C | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 596 |
| Isotype: | IgG | Swiss Prot: | P10415 |
| purity: | Affinity purification |
| Background: |
| Bcl-2 exerts a survival function in response to a wide range of apoptotic stimuli through inhibition of mitochondrial cytochrome c release (1). It has been implicated in modulating mitochondrial calcium homeostasis and proton flux (2). Several phosphorylation sites have been identified within Bcl-2 including Thr56, Ser70, Thr74, and Ser87 (3). It has been suggested that these phosphorylation sites may be targets of the ASK1/MKK7/JNK1 pathway and that phosphorylation of Bcl-2 may be a marker for mitotic events (4,5). Mutation of Bcl-2 at Thr56 or Ser87 inhibits its anti-apoptotic activity during glucocorticoid-induced apoptosis of T lymphocytes (6). Interleukin-3 and JNK-induced Bcl-2 phosphorylation at Ser70 may be required for its enhanced anti-apoptotic functions (7). |
| Reactivity | Human |
| Tested applications | FC |
| Clonality | Monoclonal Antibody |
| Calculated MW | 26 kDa |
| Recommended Dilutions |
FC 1:50
|
| Immunogen | A synthetic phosphopeptide corresponding to residues surrounding Ser70 of human Bcl-2 |
| Storage | Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | Bcl-2, PPP1R50 |
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