| No | Size | Price | Availability | |
| ARM7535-21C | 50ul | 1500.00 | In Stock |  |
| ARM7535-21C | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 7535 |
| Isotype: | IgG | Swiss Prot: | P43403 |
| purity: | Affinity purification |
| Background: |
| This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene. |
| Reactivity | Human |
| Tested applications | FC |
| Clonality | Monoclonal Antibody |
| Calculated MW | 70 kDa |
| Recommended Dilutions |
FC 1:50
|
| Immunogen | A synthetic peptide corresponding to residues surrounding the amino-terminus of human Zap-70 |
| Storage | Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | FLJ17670, FLJ17679, SRK, STD, TZK, ZAP-70 |
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