| No | Size | Price | Availability | |
| ARM3059P-21C | 50ul | 1500.00 | In Stock |  |
| ARM3059P-21C | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 3059 |
| Isotype: | IgG | Swiss Prot: | P14317 |
| purity: | Affinity purification |
| Background: |
| HS1 (HCLS1, LckBP1, p75) is a protein kinase substrate that is expressed only in tissues and cells of hematopoietic origin (1,2). HS1 contains four cortactin repeats and a single SH3 domain (2). This intracellular protein is phosphorylated following immune receptor activation, which promotes recruitment of HS1 to the immune synapse (3-5). Phosphorylation of HS1 is required to regulate actin dynamics and provide docking sites for many other signaling molecules, such as Vav1 and PLCγ1 (6). HS1 also plays an important role in platelet activation (7).HS1 is rapidly phosphorylated at Tyr397 by Syk and/or Lyn kinases following immune receptor stimulation and thrombin-mediated platelet stimulation. This phosphorylation is an important step in cytoskeletal rearrangement and signaling complex formation (6-10). |
| Reactivity | Human, (Mouse, Rat) |
| Tested applications | FC |
| Clonality | Monoclonal Antibody |
| Calculated MW | 80 kDa |
| Recommended Dilutions |
FC 1:50
|
| Immunogen | A synthetic phosphopeptide corresponding to residues surrounding Tyr405 of mouse HS1 protein This site corresponds to Tyr397 of human HS1 protein |
| Storage | Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | CTTNL, HS1 |
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