| No | Size | Price | Availability | |
| ARM3654-21C | 50ul | 1500.00 | In Stock |  |
| ARM3654-21C | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 3654 |
| Isotype: | IgG | Swiss Prot: | P51617 |
| purity: | Affinity purification |
| Background: |
| Interleukin-1 (IL-1) receptor-associated kinase (IRAK) is a serine/threonine-specific kinase that can be coprecipitated in an IL-1-inducible manner with the IL-1 receptor (1). The mammalian family of IRAK molecules contains four members (IRAK1, IRAK2, IRAK3/IRAK-M, and IRAK4). The binding of IL-1 to IL-1 receptor type I (IL-1RI) initiates the formation of a complex that includes IL-1RI, AcP, MyD88, and IRAKs (2). IRAK undergoes autophosphorylation shortly after IL-1 stimulation. The subsequent events involve IRAK dissociation from the IL-1RI complex, its ubiquitination, and its association with two membrane-bound proteins: TAB2 and TRAF6. The resulting IRAK-TRAF6-TAB2 complex is then released into the cytoplasm where it activates protein kinase cascades, including TAK1, IKKs, and the stress-activated kinases (3). |
| Reactivity | Human, Monkey, Mouse |
| Tested applications | W |
| Clonality | Monoclonal Antibody |
| Calculated MW | 78-105 kDa |
| Recommended Dilutions |
WB 1:1000
|
| Immunogen | A synthetic peptide corresponding to residues near the carboxy terminus of mouse IRAK1 protein |
| Storage | Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | IRAK1, IRAK, pelle |
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