| No | Size | Price | Availability | |
| AMM5599-16 | 50ul | 1500.00 | In Stock |  |
| AMM5599-16 | 100ul | 2000.00 | In Stock | |
| Source: | Mouse | Gene Id: | 5599 |
| Isotype: | IgG1 | Swiss Prot: | P45983 |
| purity: | Affinity purification |
| Background: |
| The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq |
| Reactivity | Human, Mouse, Rat |
| Tested applications | WB |
| Clonality | Monoclonal Antibody |
| Calculated MW | 46,54 kDa |
| Recommended Dilutions |
WB 1-5 ug/mL
|
| Immunogen | A recombinant protein corresponding to human MAPK8 |
| Storage | Store at -20°C in PBS pH 7.3 (1% BSA,0.08% sodium azide).Avoid freeze/thaw cycles. |
| Synonym | JNK, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1 |
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