TP53 Mouse Monoclonal Antibody
No Size Price Availability  
AMM7157-12 50ul 1500.00 In Stock
AMM7157-12 100ul 2000.00 In Stock
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Source: Rabbit Gene Id: 7157
Isotype: IgG Swiss Prot: P04637
purity: Affinity purification
Background:
This gene encodes tumor protein p53, which responds to diverse cellular stresses to regulate target genes that induce cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines, where it's believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing transcription activation, DNA-binding, and oligomerization domains. It is postulated to bind to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor. Mutants of p53 that frequently occur in a number of different human cancers fail to bind the consensus DNA binding site, and hence cause the loss of tumor suppressor activity. Alterations of this gene occur not only as somatic mutations in human malignancies, but also as germline mutations in some cancer-prone families with Li-Fraumeni syndrome. Multiple p53 variants due to alternative promoters and multiple alternative splicing have been found. These variants encode distinct isoforms, which can regulate p53 transcriptional activity. [provided by RefSeq
Reactivity Human
Tested applications IHC
Clonality Monoclonal Antibody
Calculated MW 53 kDa
Recommended Dilutions
IHC 1:100-1:500
Immunogen A synthetic peptide corresponding to N-terminus of human TP53
Storage Store at 4°C in 20 mM Tris-HCl, pH 8.0 (20 mg/mL BSA, 0.05% sodium azide).
Synonym BCC7, FLJ92943, LFS1, TRP53, p53
This product is for research use only, not for diagnostic or therapeutic use!

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