| No | Size | Price | Availability | |
| AMMC001-11 | 50ul | 1500.00 | In Stock |  |
| AMMC001-11 | 100ul | 2000.00 | In Stock | |
| Source: | Mouse | Gene Id: | 999/1000/1001/1002 |
| Isotype: | IgG1 | Swiss Prot: | P12830 P19022 P22223 P55283 |
| purity: | Affinity purification |
| Background: |
| Cadherins are a superfamily of transmembrane glycoproteins that contain cadherin repeats of approximately 100 residues in their extracellular domain. Cadherins mediate calcium-dependent cell-cell adhesion and play critical roles in normal tissue development (1). The classic cadherin subfamily includes N-, P-, R-, B-, and E-cadherins, as well as about ten other members that are found in adherens junctions, a cellular structure near the apical surface of polarized epithelial cells. The cytoplasmic domain of classical cadherins interacts with β-catenin, γ-catenin (also called plakoglobin), and p120 catenin. β-catenin and γ-catenin associate with α-catenin, which links the cadherin-catenin complex to the actin cytoskeleton (1,2). While β- and γ-catenin play structural roles in the junctional complex, p120 regulates cadherin adhesive activity and trafficking (1-4). Investigators consider E-cadherin an active suppressor of invasion and growth of many epithelial cancers (1-3). Research studies indicate that cancer cells have up-regulated N-cadherin in addition to loss of E-cadherin. This change in cadherin expression is called the "cadherin switch". N-cadherin cooperates with the FGF receptor, leading to overexpression of MMP-9 and cellular invasion (3). Research studies have shown that in endothelial cells, VE-cadherin signaling, expression, and localization correlate with vascular permeability and tumor angiogenesis (5,6). Investigators have also demonstrated that expression of P-cadherin, which is normally present in epithelial cells, is also altered in ovarian and other human cancers (7,8). |
| Reactivity | Chiken, Human, Mouse, Rabbit, Rat, Snake |
| Tested applications | WB IHC |
| Clonality | Monoclonal Antibody |
| Calculated MW | 130-150 kDa |
| Recommended Dilutions |
WB 1-2 ug/mL
IHC 2-4 ug/mL
|
| Immunogen | A mixture of synthetic peptides (conjugated with KLH) corresponding to C-terminus of chicken N-Cadherin with an extra N-terminus lysine residue (24 amino acids) |
| Storage | Store at -20°C on dry atmosphere.After reconstitution with 1 mL of 1.2% sodium acetate or neutral PBS and concentration will be 100 ug/mL, store at -20°C or lower.Avoid freeze/thaw cycles. |
| Synonym | / |
沪ICP备15003525号 Copyright ©, 2013-2019, Yihyson All Rights Reserved. 
