Source: | Mouse | Gene Id: | 4744 |
Isotype: | IgG1 Kappa | Swiss Prot: | P12036 |
purity: | Protein G affinity chromatography |
Background: |
Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and functionally maintain neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the heavy neurofilament protein. This protein is commonly used as a biomarker of neuronal damage and susceptibility to amyotrophic lateral sclerosis (ALS) has been associated with mutations in this gene. [provided by RefSeq |
Reactivity | Human, Mouse |
Tested applications | IHC |
Clonality | Monoclonal Antibody |
Calculated MW | 180-220 kDa |
Recommended Dilutions |
IHC 1:200-1:400
|
Immunogen | The Triton-X 100 insoluble protein fraction from rat brain |
Storage | Store at 4°C. For long term storage store at -20°C in PBS (0.05% BSA, 0.05% sodium azide). Avoid freeze/thaw cycles. |
Synonym | NFH |
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