| No | Size | Price | Availability | |
| AMM920-13 | 50ul | 1500.00 | In Stock |  |
| AMM920-13 | 100ul | 2000.00 | In Stock | |
| Source: | Mouse | Gene Id: | 920 |
| Isotype: | IgM | Swiss Prot: | P01730 |
| purity: | Affinity purification |
| Background: |
| Cluster of Differentiation 4 (CD4) is a glycoprotein composed of an amino-terminal extracellular domain (four domains: D1-D4 with Ig-like structures), a transmembrane part and a short cytoplasmic tail. CD4 is expressed on the surface of T helper cells, regulatory T cells, monocytes, macrophages and dendritic cells, and plays an important role in the development and activation of T cells. On T cells, CD4 is the co-receptor for the T cell receptor (TCR), and these two distinct structures recognize the Antigen–Major Histocompatibility Complex (MHC). Specifically, the D1 domain of CD4 interacts with the β2-domain of the MHC class II molecule. CD4 ensures specificity of the TCR–antigen interaction, prolongs the contact between the T cell and the antigen presenting cell and recruits the tyrosine kinase Lck, which is essential for T cell activation (1). |
| Reactivity | Human |
| Tested applications | IP FC |
| Clonality | Monoclonal Antibody |
| Calculated MW | 55 kDa |
| Recommended Dilutions |
FC 10 ug/mL
|
| Immunogen | Native human peripheral blood leukemia T-cells |
| Storage | Store at 4°C in PBS, pH 7.4 (15 mM sodium azide). Do not freeze. |
| Synonym | CD4mut |
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