| No | Size | Price | Availability | |
| AMM5925-14 | 50ul | 1500.00 | In Stock |  |
| AMM5925-14 | 100ul | 2000.00 | In Stock | |
| Source: | Mouse | Gene Id: | 5925 |
| Isotype: | IgG1 | Swiss Prot: | P06400 |
| purity: | Affinity purification |
| Background: |
| The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. |
| Reactivity | Chiken, Human, Mouse |
| Tested applications | IP |
| Clonality | Monoclonal Antibody |
| Calculated MW | 110 kDa |
| Recommended Dilutions | |
| Immunogen | A recombinant protein corresponding to amino acids 393-572 of human RB1 |
| Storage | Store at -20°C in PBS (0.08% sodium azide).Avoid freeze/thaw cycles. |
| Synonym | RB, pRb, OSRC, pp110, p105-Rb |
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