CD4 Mouse Monoclonal Antibody
No Size Price Availability  
AMM920-12 50ul 1500.00 In Stock
AMM920-12 100ul 2000.00 In Stock
  • Details
  • FAQs
  • Manual
Source: Mouse Gene Id: 920
Isotype: IgG2 Swiss Prot: P01730
purity: Affinity purification
Background:
Cluster of Differentiation 4 (CD4) is a glycoprotein composed of an amino-terminal extracellular domain (four domains: D1-D4 with Ig-like structures), a transmembrane part and a short cytoplasmic tail. CD4 is expressed on the surface of T helper cells, regulatory T cells, monocytes, macrophages and dendritic cells, and plays an important role in the development and activation of T cells. On T cells, CD4 is the co-receptor for the T cell receptor (TCR), and these two distinct structures recognize the Antigen–Major Histocompatibility Complex (MHC). Specifically, the D1 domain of CD4 interacts with the β2-domain of the MHC class II molecule. CD4 ensures specificity of the TCR–antigen interaction, prolongs the contact between the T cell and the antigen presenting cell and recruits the tyrosine kinase Lck, which is essential for T cell activation (1).
Reactivity Mouse
Tested applications IP FC
Clonality Monoclonal Antibody
Calculated MW 55 kDa
Recommended Dilutions
Immunogen Native purified CD4 from human peripheral blood T cells
Storage Store at -20°C on dry atmosphere.After reconstitution with deionized water, store at -20°C or lower.Avoid freeze/thaw cycles.
Synonym CD4mut
This product is for research use only, not for diagnostic or therapeutic use!

backtop
QQ
service center
Contact Us