Ubiquitin Mouse Monoclonal Antibody
No Size Price Availability  
AMMT015-12 50ul 1500.00 In Stock
AMMT015-12 100ul 2000.00 In Stock
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Source: Mouse Gene Id: /
Isotype: IgG1 Swiss Prot: /
purity: Affinity purification
Background:
Ubiquitin is a conserved polypeptide unit that plays an important role in the ubiquitin-proteasome pathway. Ubiquitin can be covalently linked to many cellular proteins by the ubiquitination process, which targets proteins for degradation by the 26S proteasome. Three components are involved in the target protein-ubiquitin conjugation process. Ubiquitin is first activated by forming a thiolester complex with the activation component E1; the activated ubiquitin is subsequently transferred to the ubiquitin-carrier protein E2, then from E2 to ubiquitin ligase E3 for final delivery to the epsilon-NH2 of the target protein lysine residue (1-3). The ubiquitin-proteasome pathway has been implicated in a wide range of normal biological processes and in disease-related abnormalities. Several proteins such as IκB, p53, cdc25A, and Bcl-2 have been shown to be targets for the ubiquitin-proteasome process as part of regulation of cell cycle progression, differentiation, cell stress response, and apoptosis (4-7).
Reactivity Human
Tested applications WB ELISA IP
Clonality Monoclonal Antibody
Calculated MW 18 kDa
Recommended Dilutions
WB 1:1800
Immunogen A recombinant GST fusion protein corresponding to full length human Ubiquitin
Storage Store at -20°C in HEPES, 150 mM NaCl (50% glycerol, 0.01% BSA, 0.03% sodium azide).Avoid freeze/thaw cycles.
Synonym /
This product is for research use only, not for diagnostic or therapeutic use!

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