CDKN2C Mouse Monoclonal Antibody
No Size Price Availability  
AMM1031-11 50ul 1500.00 In Stock
AMM1031-11 100ul 2000.00 In Stock
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Source: Mouse Gene Id: 1031
Isotype: IgG1 Swiss Prot: P42773
purity: Affinity purification
Background:
Cyclin-dependent kinases (CDKs) are activated in part by forming complexes with cyclins. For example, CDK4 and CDK6 associate with the D-type cyclins and phosphorylate the retinoblastoma protein. This phosphorylation is a necessary event for cells to enter S-phase (1). The inhibitors of CDK4 (INK4) family include p15 INK4B, p16 INK4A, p18 INK4C and p19 INK4D. p18 has been shown to function as a haploinsufficient tumor suppressor in vivo (2). All INK4 proteins are composed of 32 amino acid ankyrin motifs and selectively inhibit CDK4/6 activity. Mutational analyses of p18 implicate the third and the amino-terminal portion of the fourth ankyrin repeat in mediating binding to CDK4/6 (3). The interaction of INK4 family members can be a binary complex with CDK4/6 or ternary complex with cyclin D-bound CDK4/6 and ultimately results in the inhibition of cell cycle progression (4,5).
Reactivity /
Tested applications WB ELISA IP IF
Clonality Monoclonal Antibody
Calculated MW 18 kDa
Recommended Dilutions
Immunogen A recombinant protein corresponding to amino acids 18-530 of HA (A/Anhui/1/2005)(H5N1)
Storage Store at 4°C in PBS. Do not freeze.
Synonym INK4C, p18, p18-INK4C
This product is for research use only, not for diagnostic or therapeutic use!

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