CDKN1A Mouse Monoclonal Antibody
No Size Price Availability  
AMM1026-11 50ul 1500.00 In Stock
AMM1026-11 100ul 2000.00 In Stock
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Source: Mouse Gene Id: 1026
Isotype: IgG1 Swiss Prot: P38936
purity: Affinity purification
Background:
This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Two alternatively spliced variants, which encode an identical protein, have been reported. [provided by RefSeq
Reactivity Human
Tested applications WB IHC ELISA ICC
Clonality Monoclonal Antibody
Calculated MW 21 kDa
Recommended Dilutions
Immunogen Native purified human CDKN1A
Storage Store at 4°C in PBS, pH 7.4 (15 mM sodium azide). Do not freeze.
Synonym CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1
This product is for research use only, not for diagnostic or therapeutic use!

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