CD4 Mouse Monoclonal Antibody
No Size Price Availability  
AMM920-11 50ul 1500.00 In Stock
AMM920-11 100ul 2000.00 In Stock
  • Details
  • FAQs
  • Manual
Source: Mouse Gene Id: 920
Isotype: IgG2a Swiss Prot: P01730
purity: Affinity purification
Background:
Cluster of Differentiation 4 (CD4) is a glycoprotein composed of an amino-terminal extracellular domain (four domains: D1-D4 with Ig-like structures), a transmembrane part and a short cytoplasmic tail. CD4 is expressed on the surface of T helper cells, regulatory T cells, monocytes, macrophages and dendritic cells, and plays an important role in the development and activation of T cells. On T cells, CD4 is the co-receptor for the T cell receptor (TCR), and these two distinct structures recognize the Antigen–Major Histocompatibility Complex (MHC). Specifically, the D1 domain of CD4 interacts with the β2-domain of the MHC class II molecule. CD4 ensures specificity of the TCR–antigen interaction, prolongs the contact between the T cell and the antigen presenting cell and recruits the tyrosine kinase Lck, which is essential for T cell activation (1).
Reactivity Human
Tested applications IP FC
Clonality Monoclonal Antibody
Calculated MW 55 kDa
Recommended Dilutions
Immunogen Native purified CD4 from human thymocytes and T lymphocytes
Storage Store at 4°C. For long term storage store at -20°C in TBS pH 8.0 (15 mM sodium azide). Avoid freeze/thaw cycles.
Synonym CD4mut
This product is for research use only, not for diagnostic or therapeutic use!

backtop
QQ
service center
Contact Us