REPS1 Rabbit Monoclonal Antibody
No Size Price Availability  
ARM85021-11 50ul 1500.00 In Stock
ARM85021-11 100ul 2000.00 In Stock
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Source: Rabbit Gene Id: 85021
Isotype: IgG Swiss Prot: Q96D71
purity: Affinity purification
Background:
REPS1 is a RalBP1-associated EH-homology domain containing protein. The sequence of REPS1 has an EH domain, followed by two proline-rich segments, and a C-terminal coiled-coil domain for binding to RalBP1. The EH domain of REPS1 interacts with the NPF motif of Rab11-FIP2, mediates their colocalization to endosome vesicles, and influences EGFR endocytosis. The two proline-rich regions of REPS1 are important for binding to the SH3 domain of GRK/GRB2 and further regulate EGFR downstream signaling. The proline-rich regions of REPS1 have also been shown to interact with the SH3 domain of intersectin1 (ITSN1) and contribute to ITSN1/SGIP1/REPS1 complex formation on clathrin-coated pits. Three alternatively spliced isoforms of REPS1 have been identified.
Reactivity Human
Tested applications WB ELISA
Clonality Monoclonal Antibody
Calculated MW 125 kDa
Recommended Dilutions
Immunogen A synthetic peptide of human REPS1 is used for rabbit immunization
Storage Store at -20°C or lower in PBS(pH 7.4). Avoid freeze/thaw cycles.
Synonym RALBP1
This product is for research use only, not for diagnostic or therapeutic use!

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