RABGEF1 Rabbit Monoclonal Antibody
No Size Price Availability  
ARM27342-11 50ul 1500.00 In Stock
ARM27342-11 100ul 2000.00 In Stock
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Source: Rabbit Gene Id: 27342
Isotype: IgG Swiss Prot: Q9UJ41
purity: Affinity purification
Background:
Rabex-5, also called RabGEF1 and RAP1, was identified as a guanine nucleotide exchange factor (GEF) for Rab5, a member of the Ras superfamily of small Rab GTPases. Rabex-5 generates the GTP-bound active form of Rab5 and forms a tight association with its effector protein Rabaptin-5. This complex localizes to endosomal membranes where it functions as a key regulator of vesicular trafficking during early endocytosis. Rabex-5 is also monoubiquitinated and has ubiquitin ligase activity that regulates its recruitment to early endosomes. The conformational change between Rab5 GTP/GDP states is essential for its biological function as a rate limiting regulator at multiple steps during endocytosis. Through its control of endosomal trafficking and endocytosis, Rabex-5 has been shown to negatively regulate NGF-mediated neurite outgrowth as well as FcεRI-dependent mast cell activation.
Reactivity Human
Tested applications WB ELISA
Clonality Monoclonal Antibody
Calculated MW 60-80 kDa
Recommended Dilutions
Immunogen A synthetic peptide of human RABGEF1 is used for rabbit immunization
Storage Store at -20°C or lower in PBS(pH 7.4). Avoid freeze/thaw cycles.
Synonym FLJ32302, RABEX5, rabex-5
This product is for research use only, not for diagnostic or therapeutic use!

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