| GTPase Regulator Associated with Focal Adhesion Kinase-1 (GRAF1), is a GTPase-activating protein for the small G proteins RhoA and Cdc42. It is composed of an N-terminal BAR domain, a PH domain, a RhoGAP domain, a proline-rich domain, and a C-terminal SH3 domain. GRAF1 contributes to the clathrin-independent carriers/GPI-enriched early endosomal compartments (CLIC/GEEC) pathway, and was the first specific protein component of this endocytic pathway to be discovered. GRAF1 was identified as an important protein necessary for adeno-associated virus 2 infection. In addition, research studies have linked GRAF1 to mental retardation, skeletal muscle differentiation, and myeloid leukemia. |
