| No | Size | Price | Availability | |
| AMM9788-11 | 50ul | 1500.00 | In Stock |  |
| AMM9788-11 | 100ul | 2000.00 | In Stock | |
| Source: | Mouse | Gene Id: | 9788 |
| Isotype: | IgG1 Kappa | Swiss Prot: | O43312 |
| purity: | Affinity purification |
| Background: |
| Metastasis suppressor 1 (MTSS1) is a multi-functional scaffold protein that was initially discovered using a differential display technique that uncovered proteins missing from bladder cancer cell lines. MTSS1 (also known as Missing in Metastasis or MIM) is a cytoskeletal remodeling protein that contains a C-terminal WH2 actin-binding motif. Presence of an IMD (IRSp53/MIM homology) domain allows MTSS1 to induce F-actin bundling and filopodia formation in cells. MTSS1 binds to and activates Rac, a protein known to promote the formation of filopodia and lamellipodia. The receptor tyrosine phosphatase δ (PTPRD) is associated with MTSS1 and is required for MTSS1-dependent cytoskeletal change. MTSS1 is a Shh responsive gene that can help regulate Gli transcriptional activity. Transcription of MTSS1 is regulated by DNA methylation. |
| Reactivity | Human |
| Tested applications | WB ELISA |
| Clonality | Monoclonal Antibody |
| Calculated MW | 95-105 kDa |
| Recommended Dilutions | |
| Immunogen | MTSS1 (AAH23998, 346 aa ~ 445 aa) partial recombinant protein with GST tag |
| Storage | Store at -20°C or lower in ascites fluid. Avoid freeze/thaw cycles. |
| Synonym | DKFZp781P2223, FLJ44694, KIAA0429, MIM, MIMA, MIMB |
沪ICP备15003525号 Copyright ©, 2013-2019, Yihyson All Rights Reserved. 
