MPZL1 Rabbit Monoclonal Antibody
No Size Price Availability  
ARM9019-11 50ul 1500.00 In Stock
ARM9019-11 100ul 2000.00 In Stock
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Source: Rabbit Gene Id: 9019
Isotype: IgG Swiss Prot: O95297
purity: Affinity purification
Background:
PZR (Protein zero related) is an immunoglobulin superfamily protein that specifically binds the tyrosine phosphatase SHP-2 through its intracellular immunoreceptor tyrosine-based inhibitory motifs (ITIMs). PZR is phosphorylated by c-Src, c-Fyn, c-Lyn, Csk, and c-Abl. PP1, a Src family kinase inhibitor, inhibits PZR phosphorylation. There are three alternatively spliced isoforms, designated as PZR, PZRa, and PZRb; both PZRa and PZRb lack ITIMs. PZR is the main receptor of ConA and has an important role in cell signaling via c-Src. PZR is expressed in many cell types and is localized to cell contacts and intracellular granules in BAECs and mesothelioma (REN) cells. PZR has been implicated as a cell adhesion protein that may be involved in SHP-2-dependent signaling at interendothelial cell contacts. Hypertyrosine phosphorylation of PZR was observed during embryogenesis in a mouse model of Noonan syndrome.
Reactivity Human
Tested applications WB ELISA
Clonality Monoclonal Antibody
Calculated MW 29.1 kDa
Recommended Dilutions
Immunogen A synthetic peptide of human MPZL1 is used for rabbit immunization
Storage Store at -20°C or lower in PBS(pH 7.4). Avoid freeze/thaw cycles.
Synonym FLJ21047, PZR, PZR1b, PZRa, PZRb
This product is for research use only, not for diagnostic or therapeutic use!

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