TCL1A Mouse Monoclonal Antibody
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AMM8115-12 50ul 1500.00 In Stock
AMM8115-12 100ul 2000.00 In Stock
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Source: Mouse Gene Id: 8115
Isotype: IgG2a Kappa Swiss Prot: P56279
purity: Affinity purification
Background:
TCL1 (T cell leukemia 1), MTCP1 and TCL1b belong to the TCL1 proto-oncogene family, and their products are involved in Akt activation during embryonic development, T cell leukemias, prolymphocytic leukemias and B cell lymphomas. The Akt association domain of TCL1 binds with the PH domain of Akt. The formation of an oligomeric TCL-Akt complex is required for TCL1 coactivator function and results in phosphorylation and activation of Akt. Furthermore, functional analysis indicates that the interaction between TCL1 and Akt promotes translocation of Akt to the nucleus. These findings are supported by the crystal structure of TCL1, which suggests that TCL1 may participate in molecular transport.
Reactivity Human
Tested applications S-ELISA ELISA
Clonality Monoclonal Antibody
Calculated MW 14 kDa
Recommended Dilutions
Immunogen TCL1A (NP_0688011, 61 aa ~ 114 aa) partial recombinant protein with GST tag
Storage Store at -20°C or lower in PBS(pH 7.4). Avoid freeze/thaw cycles.
Synonym TCL1
This product is for research use only, not for diagnostic or therapeutic use!

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