WRN Mouse Monoclonal Antibody
No Size Price Availability  
AMM7486-11 50ul 1500.00 In Stock
AMM7486-11 100ul 2000.00 In Stock
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Source: Mouse Gene Id: 7486
Isotype: IgG1 Kappa Swiss Prot: Q14191
purity: Affinity purification
Background:
This gene encodes a member of the RecQ subfamily and the DEAH (Asp-Glu-Ala-His) subfamily of DNA and RNA helicases. DNA helicases are involved in many aspects of DNA metabolism, including transcription, replication, recombination, and repair. This protein contains a nuclear localization signal in the C-terminus and shows a predominant nucleolar localization. It possesses an intrinsic 3' to 5' DNA helicase activity, and is also a 3' to 5' exonuclease. Based on interactions between this protein and Ku70/80 heterodimer in DNA end processing, this protein may be involved in the repair of double strand DNA breaks. Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by premature aging.
Reactivity Human
Tested applications WB ELISA
Clonality Monoclonal Antibody
Calculated MW 200 kDa
Recommended Dilutions
Immunogen WRN (NP_000544, 1322 aa ~ 1432 aa) partial recombinant protein with GST tag
Storage Store at -20°C or lower in PBS(pH 7.4). Avoid freeze/thaw cycles.
Synonym DKFZp686C2056, RECQ3, RECQL2, RECQL3
This product is for research use only, not for diagnostic or therapeutic use!

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