RAP1B Rabbit Monoclonal Antibody
No Size Price Availability  
ARM5908-11 50ul 1500.00 In Stock
ARM5908-11 100ul 2000.00 In Stock
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Source: Rabbit Gene Id: 5908
Isotype: IgG Swiss Prot: P61224
purity: Affinity purification
Background:
Rap1 and Rap2 belong to the Ras subfamily of small GTPases and are activated by a wide variety of stimuli through integrins, receptor tyrosine kinases (RTKs), G-protein coupled receptors (GPCR), death domain associated receptors (DD-R) and ion channels. Like other small GTPases, Rap activity is stimulated by guanine nucleotide exchange factors (GEF) and inactivated by GTPase activating proteins (GAP). A wide variety of Rap GEFs have been identified: C3G connects Rap1 with RTKs through adaptor proteins such as Crk, Epacs (or cAMP-GEFs) transmit signals from cAMP, and CD-GEFs (or CalDAG-GEFs) convey signals from either or both Ca2+ and DAG. Rap1 primarily regulates multiple integrin-dependent processes such as morphogenesis, cell-cell adhesion, hematopoiesis, leukocyte migration and tumor invasion. Rap1 may also regulate proliferation, differentiation and survival through downstream effectors including B-Raf, PI3K, RalGEF and phospholipases (PLCs). Rap1 and Rap2 are not fuctionally redundant as they perform overlapping but distinct functions. Recent research indicates that Rap2 regulates Dsh subcellular localization and is required for Wnt signaling in early development.
Reactivity Human
Tested applications WB ELISA
Clonality Monoclonal Antibody
Calculated MW 21 kDa
Recommended Dilutions
Immunogen A synthetic peptide of human RAP1B is used for rabbit immunization
Storage Store at -20°C or lower in PBS(pH 7.4). Avoid freeze/thaw cycles.
Synonym DKFZp586H0723, K-REV, RAL1B
This product is for research use only, not for diagnostic or therapeutic use!

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